UsesUsed in the treatment of adults with urinary tract infections, both uncomplicated (cystitis) and complicated urinary tract infections Sexually transmitted diseases (gonorrhea), genital infection, prostate infection (prostatitis), infections of the stomach or intestines (travelers’ diarrhea) and eye infection
Mechanism of ActionNorfloxacin inhibits bacterial reproduction by inhibiting DNA formation, thereby killing the bacteria
DosageAdult- The recommended dosage is one 400-mg tablet once daily for the duration given above Ophthalmic- As 0.3% solution: Instill 1-2 drops 4 times/day for upto 7 days. May increase to 2 hourly for the 1st day in more severe infections
Side EffectsMost Common- Nausea, abdominal pain, indigestion, constipation, gas and heartburn Gastrointestinal- Abdominal pain, constipation, diarrhea, dry mouth, indigestion/heartburn, flatulence and vomiting Miscellaneous- Itching, rash, drowsiness, back pain and fever,DRESS syndrome
Warnings/PrecautionsCaution should be exercised in patients with history of stomach infection, nerve problems, myasthenia gravis, brain tumor or injury, Alzheimer disease, seizures, glucose-6-phosphate dehydrogenase (G-6PD) deficiency, any allergy, who are taking other medications, during pregnancy and breastfeeding It may cause dizziness, lightheadedness, or tiredness, do not drive a car or operate machinery while taking this medication Avoid exposure to sunlight