UsesPantoprazoleis used to treat erosive esophagitis (damage to the esophagus from stomach acid) It also used forother conditions involving excess stomach acid such as Zollinger-Ellison syndrome in prevention of intestinal or stomach ulcers in patients caused by prolonged pain killer use
Mechanism of Action- Pantoprazole belongs to a class of drugs known as proton pump inhibitors
- It acts by reducing the amount of acid produced in the stomach
DosageGastroesophageal reflux disease (GERD) - 20-40 mg /day in the morning for 4 to 8 weeks if needed. Maintenance: 20-40 mg/day IV- 40 mg/day for 7 to 10 days Erosive esophagitis -Adults 40 mg/day up to 8 weeks Children -20mg/day up to 8weeks Zollinger-Ellison Syndrome -40mg twice daily. IV: 80 mg every 12 hour
Side EffectsVertigo Increased risk of bone fractures Pruritis Pyrexia Diarrhea Blurred vision Dizzines
Warnings/PrecautionsLong-term therapy may lead to bacterial overgrowth in the GI tract, atrophic gastritis Monitor liver function regularly (if enzymes increase, discontinue) because it may lead to liver damage Caution needed during pregnancy; not recommended in children <18 year. Patient may develop with increased risk of Clostridium difficile associated diarrhea (CDAD)