UsesThis medication is a tricyclic antidepressant, prescribed for depression It is also prescribed for migraine and nerve pain It corrects the imbalance of chemical substances acting on the nervous system
Mechanism of Action- Amitriptyline is a dibenzocycloheptadiene tricyclic antidepressant
- It increases synaptic concentration of serotonin and/or norepinephrine in the CNS by blocking the neuronal reuptake of norepinephrine and serotonin
DosageDepression- Initial: 50-75 mg/day; up to 150 mg/day if needed. Max: 300 mg/day in severe cases Neuropathic pain- Initial: 10-25 mg/day at night, up to 75 mg/day if needed Migraine prophylaxis- Initial: 10 mg/day at night
Side EffectsHypotension Tachycardia Palpitation Arrhythmias Heart block Stroke Hallucinations Anxiety Excitement Restlessness Insomnia Nightmares Urinary retention Skin rash Urticaria Nausea, vomiting, anorexia, epigastric distress, diarrhoea
Warnings/PrecautionsNot intended for treatment of bipolar depression. Avoid abrupt withdrawal Patient at risk of seizures, w/ DM, narrow angle glaucoma, urinary retention, prostatic hyperplasia, chronic constipation, history of CV disease Renal and hepatic impairment