UsesPhenylephrineis used to treat nasal and sinus congestion, or congestion of the tubes that drain fluid from your inner ears, called the eustachian tube Phenylephrine is a decongestant and is used to relieve blocked nose caused by common cold or in seasonal nasal allergies (hay fever)
Mechanism of Action- Phenylephrine is a sympathomimetic with mainly direct effects on alpha-adrenergic receptors and weak beta-adrenergic activity
- It causes vasoconstriction of the arterioles of the nasal mucosa and conjunctiva; activates the dilator muscle of the pupil to cause contraction; produces vasoconstriction of arterioles in the body and produces systemic arterial vasoconstriction
DosageOral -Nasal congestion - Adult:As hydrochloride: 10 mg every 4 hour, max 60 mg daily; or 12 mg up to 4 times daily Child:2-6 yr: As tannate salt: 1.87-3.75 mg every 12 hour. 6-12 yr: As hydrochloride salt: 10 mg every 4 hour; as tannate salt: 3.75-7.5 mg every 12 hour. >12 yr: As hydrochloride salt: 10-20 mg every 4 hour; as tannate salt: 7.5-15 mg every 12 hour Nasal -Nasal congestion - Adult:0.25 to 1% solution: Instill as nasal drops or a spray into each nostril every 4 hour as needed Child:2-6 yr: 0.125% or 0.16% solution: 2-3 drops into each nostril every 4 hour as needed; 6-12 yr: 0.25% solution: 2-3 drops, or 1-2 sprays, into each nostril every 4 hour as needed
Side EffectsRestlessness Difficulty in passing urine Swelling of the face Bradycardia Difficulty in breathing
Warnings/PrecautionsOral phenylephrine should be taken with food Phenylephrine can make you restless, so don't take it too close to bedtime Do not use this medicine without doctor's advice if you are pregnant or breast feeding Smoking may worsen the effect; therefore use of tobacco should be avoided