UsesUsed to treat fits (epilepsy or seizures) and sudden, unexpected attacks of extreme fear, and worry about these attacks (panic disorder) with or without the fear of public places (agoraphobia)
Mechanism of ActionThe exact mechanism of action of clonazepam is unknown; it is however believed to enhance the action of a signaling chemical called gamma aminobutyric acid (GABA) in the brain, which helps to calm the excessive electrical nerve activity that is responsible for causing fits (seizures) and panic disorders
DosageSeizure Disorders- Adults: The initial dose should not exceed 1.5 mgday divided into three doses. It may be increased if needed Pediatric Patients: The initial dose should be between 0.01 and 0.03 mgkgday but not to exceed 0.05 mgkgday given in two or three divided doses Panic Disorder- Adults: The initial is 0.25 mg two times per day
Side EffectsDrowsiness, headache, fatigue, nervousness, lethargy, dizziness, nausea, hangover, anxiety, depression, weakness, confusion, blurred vision, abnormal dreams, and fainting Difficulty in breathing and palpitations Anemia, decreased white blood cells and platelets Vomiting, diarrhea, dry mouth and abdominal discomfort Muscle weakness and pain Hair loss and rash Painful urination, urine retention and bed-wetting Excessive sweating and burning eyes
Warnings/PrecautionsCaution should be exercised in patients with history of myasthenia gravis, kidney or liver problems, blood disorder, mental or mood problems, respiratory problem, alcohol abuse, any allergy, who are taking other medications, elderly, children, during pregnancy and breast feeding It may cause drowsiness, dizziness, lightheadedness and blurred vision, do not drive a car or operate machinery while taking this medication. It may cause unconsciousness, avoid doing unsafe tasks Patient may develop with increased risk of suicidal thoughts, watch them carefully If condition worsens, consult with your doctor Monitor liver function, complete blood cell counts, and electrocardiograms regularly while taking this medication