SIZODON FORTE 4MG/2MG TABLET

• Schizophrenia (psychiatric disorder with symptoms of emotional instability, detachment from reality, often with delusions and hallucinations, and withdrawal into the self)
• manic episodes associated with bipolar disorders

• Risperidone belongs to class of medicines called atypical antipsychotics
• It works by altering the effects of chemicals present in the brain, thereby relieving the symptoms of schizophrenia and bipolar disorders

The recommended initial dose is 2 mg/day by orally, increase from day 2 if necessary to a maximum of 16 mg/day

• Extrapyramidal effects (sudden, often jerky, involuntary motions of the head, neck, arms, body, or eyes)
• dizziness
• tiredness
• fatigue
• fever
• weight gain
• feeling hot or cold
• headache
• dry mouth
• increased appetite
• restlessness
• anxiety
• sleep problems (insomnia)
• nausea

• Caution should also be exercised in patients with history of heart diseases, liver or kidney impairment, elderly, epilepsy; Parkinsonism, and during pregnancy
• It may make you drowsy. Do not drive a car or operate machinery until you know how this medication affects you
• It may make it harder for your body to cool down when it gets very hot or warm up when it gets very cold

Trihexyphenidyl is used to treat symptoms of Parkinson’s disease (a type of nerve disease that causes movement disorder characterized by slowness of movements, muscle stiffness, uncontrolled shaking and poor balance and co-ordination) and drug-induced extra pyramidal symptoms (movement disorders similar to symptoms of Parkinson’s disease) except tardive dyskinesia (involuntary movement of face and jaw). It is often given along with levodopa (anti-Parkinson drug)

Trihexyphenidyl is an anticholinergic agent, which works by blocking the action of a chemical called acetylcholine on the nerves which results in relaxing of smooth muscles; thereby, reducing the rigidity of muscle spasm (sudden involuntary contraction of a muscle or group of muscles), tremor (uncontrolled shaking) and excessive salivation associated with Parkinson’s disease

Adult- PO- Initial: The recommended dose is 1 mg/day in 3-4 divided doses, increased gradually up to 6-10 mg/day according to response

• Anxiety
• Tachycardia
• Restlessness
• Blurring of vision
• Hallucination
• Impaired memory
• Euphoria
• Difficulty urinating and rash
• Dryness of mouth

• Trihexyphenidyl is not recommended for use in patients with tardive dyskinesia (involuntary movement of face and jaw) and in children under 18 years of age
• Trihexyphenidyl is not recommended as prophylaxis (preventive treatment) for drug-induced parkinsonism.
• Avoid abrupt discontinuation of treatment as it can result in worsening of symptoms of Parkinson’s disease or emergence of life-threatening complications (neuroleptic malignant syndrome)
• Take precautions while driving or operating machinery as trihexyphenidyl can impair mental and physical abilities
• Use trihexyphenidyl with caution in hot weather as it can increase susceptibility to heat stroke (symptoms: very high fever, inability to bear heat, nausea, vomiting etc.)
• Please consult your doctor if you are pregnant or planning to become pregnant or are breastfeeding