It has a weak estrogenic and potent antiestrogenic actions. It is expected to exert a contraceptive effect and normalise the bleeding from uterine cavity by regularising the expression of oestrogen receptors on the endometrium. As a contraceptive, it prevents proliferation and decidualisation of the endometrium, enhances blastocyst formation and slightly increases embryo transport through the oviducts
Adult- Dysfunctional uterine bleeding- 60 mg twice a week for the 1st 12 week, then 60 mg/week for up to next 12 week.
Contraception- 30 mg twice a week for the 1st 12 week, then 30 mg/week from 13th week onwards. Take 1st tab on the 1st day of menstrual cycle. Follow dose irrespective of menstrual periods
Nausea, headache, rise in blood pressure
Weight gain and delayed or prolonged menstrual period
Women who desire to be pregnant should discontinue the drug intake