diseases associated with excessive acid production (Zollinger Ellison Syndrome)
Mechanism of Action
Rabeprazole belongs to class of medications called proton pump inhibitors
It blocks the activity of the proton pumps in the stomach wall that produce acid, thereby reducing the amount of acid produced in the stomach
Dosage
Gastro-oesophageal reflux disease; erosive oesophagitis -20 mg once daily in the morning for 4-8 weeks. Maintenance: 10-20 mg once daily
For non-erosive oesophagitis -10 mg once daily for 4 week, upon symptom resolution, may continue with 10 mg once daily when needed
Healing of Duodenal Ulcers -20 mg/day after the morning meal for 4 weeks; additional therapy may be required for some patients
Zollinger-Ellison -60 mg once daily. Adjust according to patient’s needs
Side Effects
Increased risk of infections
Abdominal pain
Constipation
Chills or sore throat
Belching
Flatulence
Warnings/Precautions
Caution should be exercised in patients with history of bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds, or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing contact your doctor immediately
May increase the risk of GI infections due to acid suppressive effects, liver damage, gastric tumor
