Sevelameris used to lower high blood phosphorus (phosphate) levels in patients who are on dialysis due to severe kidney disease
Dialysis removes some phosphate from your blood, but it is difficult to remove enough to keep your phosphate levels balanced
Mechanism of Action
Sevelamer acts by binding the phosphate molecule from food in the digestive tract and decreases its absorption and consequently lowers the phosphate levels in the blood
Hyperphosphataemia in patients with chronic renal failure -
As sevelamer carbonate/HCl-Initially, 800-1600 mg tid
Doses should be adjusted based on serum phosphorus level-5.5 to <7.5 mg/dL: 800 mg tid; 7.5 to <9 mg/dL: 1.2-1.6 g tid; ≥9 mg/dL: 1.6 g tid
Patients switching from Calcium acetate based on current dosage-Calcium acetate 667 mg is equivalent to sevelamer (carbonate/HCl) 800 mg
Increased serum chloride levels
Upper abdominal pain
Increase in blood acidity
Take sevelamer tablets with meals.
Avoid taking any other medicines within 1 hour before or 3 hours after you take sevelamer.
Do not start or continue sevelamer and consult your doctor:
if you have allergy to sevelamer.
if you have problems with bowel motility such as feeling of fullness, urge to vomit (nausea), vomiting, constipation, prolonged loose motions (diarrhea) or pain in the abdomen (symptoms of active inflammatory bowel disease).
if you have undergone major surgery on your stomach or bowel.
Do not take calcium or other mineral supplements without your doctor's advice