Glibenclamideis used to treat type 2 diabetes mellitus
Mechanism of Action
Glibenclamide also known as glyburide is one of a group of medicines called sulphonylurea
It acts by promoting insulin secretion in the body, so that the blood sugars are utilized by various organs, leading to a fall in blood levels of sugar
Type 2 diabetes mellitus -
Adult:Initially, 2.5-5 mg daily, may increase weekly by increments of 2.5-15 mg daily.Doses >10 mg daily should be given in 2 divided doses. Max: 20 mg daily.
Elderly:Initially, 1.25 mg daily
morbilliform or maculopapular eruptions
Caution should be exercised in patients with history of heart attack, heart, pituitary, or thyroid disease; adrenal insufficiency, stomach problem, infection, glucose-6-phosphate dehydrogenase (G6PD) deficiency, chronic metabolic acidosis, any allergy, who are taking other medications, during pregnancy and breastfeeding
It may cause dizziness, do not drive a car or operate machinery while taking this medication
Follow the diet and exercise program as directed by your physician
During hot season this medication may lead to dehydration; to avoid this problem drink adequate fluid
Monitor kidney and liver function, fasting blood glucose, hemoglobin A1c, and complete blood cell counts regularly while taking this medication
Extreme caution needed in children less than 6 years old
It helps to control blood sugar in people with type 2 diabetes mellitus
Mechanism of Action
It decreases the amount of glucose absorbed from the food and the amount ofglucose made by liver. Metformin also increases the body's response to insulin(a natural substance that controls the amount of glucose in the blood)
Dose is based on patient’s condition
The recommended dose is 0.5 to 2.5mg in divided doses
Most Common- Diarrhea, vomiting and infection
Body as a Whole- Accidental injury, headache and infection
Gastrointestinal- Indigestion and nausea
Respiratory- Nose inflammation
It may cause dizziness, do not drink alcohol beverages while taking this medication
It may lead to dehydration; drink plenty of water to avoid this problem
Monitor blood sugar regularly
Take your food properly; otherwise it will lead to low blood sugar
Caution needed in elderly patients, children, and during pregnancy and breastfeeding
Rosiglitazone acts as an agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver
Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin
The recommended dose range is 4 to 8 mg once or twice daily
Congestive heart failure
Caution should be exercised in patients with history of liver impairment, diabetic ketoacidosis, stroke, heart problems, diabetic eye diseases, anemia, fluid retention, high blood pressure, high cholesterol, who are taking other medications, any allergy, elderly, children, during pregnancy and breastfeeding.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Follow diet and exercise program regularly as directed by your physician.
Avoid pregnancy during the treatment period.
Women may develop with increased risk of bone fracture with the following symptoms: unusual bone pain, especially in the hand, foot, or upper arm. If it is so consult with your doctor immediately.
Monitor complete blood cell counts, fasting blood sugar, hemoglobin A1c, eye examinations, and liver function regularly while taking this medication