UsesThioridazine is used in the treatment of schizophrenia (psychiatric disorder with symptoms of emotional instability, detachment from reality, often with delusions and hallucinations, and withdrawal into the self) in patients who have failed to respond to other antipsychotics
Mechanism of ActionThioridazine belongs to a class of medication called as phenothiazine antipsychotics. It acts by decreasing the activity of certain chemicals (acetylcholine, dopamine, and serotonin) in the brain which are responsible for symptoms of schizophrenia, thereby reducing abnormal excitement in brain
DosageSchizophrenia- Initial: 50-100; 3 times per day. Max: 800 mg/day in 2-4 divided doses Depression- Initial: 25 mg 3 times per day. Maintenance: 20-200 mg/day
Side EffectsAbsence of menstruation Abnormal milky discharge from the breast Blurred vision Breast engorgement Nasal stuffiness Prolongation of the qtc interval Drowsiness Peripheral edema Constipation & diarrhea Dryness of mouth Pale colored skin Inhibition of ejaculation
Warnings/PrecautionsTake precautions as long term use of thioridazine may cause neuroleptic malignant syndrome (characterized by extreme body temperature, muscle rigidity, altered mental status) and tardive dyskinesia (disorder resulting in involuntary, repetitive body movements). You may be at risk of developing hypotension (low blood pressure) during the treatment with thioridazine if you are a female or an elderly or alcoholic patient Tell your doctor if you are suffering from narrow-angle glaucoma (increased pressure inside the eyes that causes visual problem), prostatic hypertrophy (enlargement of organ called prostate), heart disease or epilepsy You should undergo regular eye examinations if you are receiving thioridazine for long term or in high doses or if you have liver disease Do not drive or operate machinery as thioridazine may impair the mental and/or physical abilities Tell your doctor if you are or planning to become pregnant or are breastfeeding