This medicine used incombination of imipenem and cilastatin eliminates bacteria that cause many kinds of infections, including pneumonia and gynecological, skin, stomach, blood, bone, joint, urinary tract, and heart valve infections.
Mechanism of Action
Cilastatin prevents the metabolism of leukotriene D4 to leukotriene E4 through the inhibition of leukotriene D4 dipeptidase
Relevant information was not found
consult your doctor if you have or have ever had seizures; a brain injury; kidney, liver, or gastrointestinal disease (especially colitis); or asthma.
consult your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking imipenem and cilastatin, call your doctor.
if you have diabetes and regularly check your urine for sugar, use Clinistix or TesTape. Do not use Clinitest tablets because this drug may cause false positive results.
Used to treat bacterial infections of lung (pneumonia), urinary tract, abdomen, blood, skin and soft tissue
It is also used to treat infections during or after delivery
It may be used in the management of fever of patients with reduced immunity due to low white blood cells (neutropenia)
Mechanism of Action
It kills bacteria by inhibiting bacterial cell wall (outer coating of bacteria) formation. As a result, the bacterial cell wall is weakened and ruptures, thereby killing the bacteria
Adult: IV- Susceptible infections- As imipenem: 1-2 g/day in divided doses 6-8 hourly
Surgical prophylaxis- As imipenem: 1 g on induction of anestha, followed by 1g3 hours later. Additional doses of 500 mg may be given at 8 and 16 hr after induction if needed
IM- Susceptible infections- As imipenem: 500 or 750 mg 12 hourly
Uncomplicated gonorrhoea- As imipenem: 500 mg as single dose
Rash and hives
Nausea, vomiting, diarrhea, tooth or tongue discoloration and altered taste
Inflammation, pain, vein inflammation and severe allergic reactions
Caution should be exercised in patients with history of seizures, brain injury, kidney, liver or gastrointestinal disease (especially colitis), asthma, who are taking other medications, any allergy, elderly, children, during pregnancy and breastfeeding
While taking this medication monitor blood sugar level in diabetic patients
It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication