This medication is prescribed for the treatment of ovarian cancer It contains platinum; stops the growth of cancer cells Mechanism of Action
Two theories exist to explain the molecular mechanism of action of carboplatin with DNA:
- Aquation, or the like-cisplatin hypothesis
- Activation, or the unlike-cisplatin hypothesis.
The former is more accepted owing to the similarity of the leaving groups with its predecessor cisplatin, while the latter hypothesis envisages a biological activation mechanism to release the active Pt2+ species
The recommended dose is 360 mg/m2when given as a single IV drug and 300 mg/m2with cyclophosphamide ,It should be given as one dose every 4 weeks Side Effects
Gastrointestinal- Loss of appetite, stomach pain, diarrhea, constipation, nausea and vomiting, mouth blistering Skin- Thinned or brittle hair Central Nervous System- Fatigue, dizziness Miscellaneous- Red urine, black or tarry tools, fever, chills, shortness of breath, swelling of ankles, abnormal sounds from outside Warnings/Precautions
Give information to your doctor about platinum compound intakes Harmful to new born babies. It may cause diminished kidney function; affects nervous system; liver function impairment Caution needed while using in elderly patients, and during breastfeeding