It is used to treat infections caused by roundworms, hookworms, threadworm, whipworm, pinworm, flukes and other parasites Mechanism of Action
Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules.The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate.ATP production decreases, causing energy depletion, immobilisation and worm death
Take this exactly as directed by your doctor. Do not take more or less than instructed by your doctor.Depending on the type of infection, you may need to take Albendazole for any length of time, ranging from 1 day to 1 month Side Effects
Stomach pain nausea vomiting headache dizziness reversible hair loss Warnings/Precautions
Perform liver function tests and blood counts before and every 2 week during high dose therapy of hydatid disease It may cause bone marrow depression It may cause dizziness. Do not drive or perform other possibly unsafe tasks until you know how you react to it In young children, the tablets should be crushed or chewed and swallowed with glass of water.