UsesPioglitazone used along with a proper diet and exercise program to control high blood sugar in patients withtype 2 diabetes
Mechanism of Action- Pioglitazone belongs to class of thiazolidinedione
- Pioglitazone decreases insulin resistance in the periphery and in the liver that helps the body make better use of insulin it produces and also decreases the glucose output from the liver
DosageAdult- The recommended dose is 15 to 30 mg once daily Max: 45 mg/day
Side EffectsBone fracture Sinuses Weight gain Infection of nose Decreased sensitivity to stimulation Inability to sleep
Warnings/PrecautionsProper diet, regular exercise, and regular blood sugar testing are important for best results of this medication. Follow the diet and exercise program given to you by your health care provider Caution should be exercised in patients with history of liver, heart, diabetic eye diseases, and polycystic ovary syndrome Increased risk of low blood sugar when used with insulin or oral hypoglycemic It may lead to edema, congestive heart failure, liver dysfunction, jaundice, and anemia It may cause ovulation in premenopausal, anovulatory women Monitor liver function before and during treatment, glucose control Stop treatment if alanine transaminase, a liver enzyme increases and remains >3 times above the upper limit of normal or if jaundice develops