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    Clomid Tablet - Uses, Precautions, Dosage, and Interactions of Clomid

    • 22651 views
    • 4.8   (6 Votes)
    Medically Reviewed by Dr. Deepika Tiwari - MS, MBBS on 31 Oct 2018 - Written by Dr. Smita Sanyal - MBBS, DGO, Infertility Certification - Grammatically Approved by Dr. Kavita Jaggi Agrawal - MS, MBBS

    Clomid tablet is used as an oral medication which is used in stimulation of ovulation. Clomiphene dosage depends on the case of the patient. Clomid precautions need to be taken in case of ovarian cancer, nursing mothers, and if the woman is pregnant. The interaction of clomid with diseases, alcohol and medicine are different.

    Clomid (clomiphene citrate tablets) is an orally administered, nonsteroidal, ovulatory stimulant selected with chemicals as 2-[p-(2-chloro-1,2-diphenylvinyl)phenoxy] triethylamine citrate (1:1). It is the chemical formula of C26H28ClNO • C6H8O7 and has a chemical mass of 598.09. Before moving on to the tablet, let us learn more about its chemical aspects first.

    Clomiphene citrate could be a pale yellow or white, odorless, crystalline powder. It is freely soluble in ethanol, soluble in methanol, slightly soluble in water, acetone, and chloroform, and insoluble in ether. Clomid could be a mixture of two geometric isomers [cis (zuclomiphene) and trans (enclomiphene)] containing between 30% and 50% of the cis-isomer. 

    Each white scored pill contains 50mg clomiphene citrate. The pill additionally contains the subsequent inactive ingredients namely pre-gelatinized cornstarch, lactose, sucrose, magnesium, and cornstarch.

    What is Clomid?

    Clomid is an oral medication, which is used to stimulate ovulation. Its works by blocking steroid hormone receptors at the hypothalamus, that is vital "hormonal control center" for the body. Once this happens, the hypothalamus is stirred to release stimulating luteinizing hormone (LH) and hormone (FSH). These naturally occurring ovarian stimulants prompt ovulation during a normal cycle.

    Dosage and Administration

    1. General Considerations

    The treatment of candidates for Clomid therapy ought to be supervised by physicians experienced in the management of gynecologic or endocrine disorders. Patients should be chosen for therapy with Clomid solely after careful diagnostic analysis. Impediments to achieving the goal of medical care should be excluded or adequately treated before starting Clomid. The therapeutic objective should be balanced with potential risks and mentioned with the patient and other concerned within the accomplishment of a pregnancy.

    Ovulation most frequently happens from five to ten days after a course of Clomid. Coitus (sexual intercourse) has to be regular to coincide with the expected time of ovulation. Relevant tests to determine ovulation could also be helpful throughout this time.

    2. Recommended Dosage

    Treatment of the chosen patient ought, to begin with, a low dose, Clomid 50mg daily (1 tablet) for five days.

    The dose has to be increased solely in those patients who do not ovulate in response to cyclic 50mg Clomid. A low dosage or length of treatment course is counseled if uncommon sensitivity to pituitary gonadotropin is suspected, like in patients with polycystic ovary syndrome (PCOS).

    The patient should be evaluated fastidiously to exclude pregnancy, ovarian enlargement, or ovarian cyst formation between every treatment cycle.

    If progestin-induced bleeding is planned, or if spontaneous uterine bleeding occurs before therapy, the regime of 50mg daily for five days can be started on or concerning the fifth day of the cycle. Therapy could also be started at any time in the patient who has had no recent uterine bleeding. Once ovulation happens at this dosage, there is no advantage to increasing the dose in subsequent cycles of treatment.

    If ovulation does not seem to occur when the first course of medical care, the second course of 100mg daily (two 50mg tablets given as one daily dose) for five days is given. This course could also be started as early as thirty days after the previous one when precautions are taken to exclude the presence of pregnancy. Increasing the indefinite quantity or length of therapy on the far side a 100mg/day for five days is not counseled.

    The majority of patients who are going to ovulate can do so after the primary course of therapy. If ovulation does not occur after three courses of therapy, additional treatment with Clomid is not recommended and therefore the patient is re-evaluated. If three ovulatory responses occur and pregnancy has not been achieved, additional treatment is not recommended. If the period does not occur after an ovulatory response, the patient ought to be re-evaluated. Long-run cyclic therapy is not recommended beyond about six cycles.

    Precautions for Clomid

    1. General

    Careful attention should be given to the choice of candidates for Clomid therapy. Pelvic examination is important prior to clomiphene citrate treatment and before every subsequent course.

    2. Carcinogenesis, Mutagenesis, Impairment of Fertility

    Long-term toxicity studies in animals have not been performed to judge the carcinogenic or mutagenic potential of Clomid tablet. Oral administration of Clomid to male rats at doses of 0.3 or 1mg/kg/day caused decreased fertility, whereas higher doses caused temporary infertility. Oral doses of 0.1 mg/kg/day in female rats temporarily interrupted the normal cyclic vaginal smear pattern and prevented conception. Doses of 0.3 mg/kg/day slightly reduced the quantity of ovulated ova and corpora lutea, whereas 3mg/kg/day inhibited ovulation process.

    3. Fetal Risk Summary

    Clomid Tablet use in pregnant women is contraindicated, as clomiphene citrate treatment does not supply profit during this population. Available human knowledge does not suggest an increased risk for congenital anomalies on top of the background population risk. However, animal reproductive toxicology studies showed an increased embryo-fetal loss and structural malformations in offspring. If this drug is used throughout pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential risks to the fetus.

    4. Clinical Concerns

    To avoid unintended Clomid administration throughout early pregnancy condition, acceptable tests ought to use throughout every treatment cycle to see whether ovulation and/or pregnancy occurs. Patients ought to be evaluated rigorously to exclude ovarian enlargement or ovarian cyst formation between every treatment cycle. The subsequent course of Clomid tablet therapy ought to be delayed until these conditions are excluded.

    5. Human Data

    The available knowledge from epidemiologic studies does not show any apparent cause and effect relationship between Clomid periconceptual exposure and an augmented risk of overall birth defects, or any specific anomaly. However, thanks to the small number of cases of no heritable anomalies occurring in Clomid treated women, these epidemiologic studies were solely ready to rule out massive variations in risk. The studies did not think about factors related to woman sub fertility and were unable to regulate for alternative necessary confounders. Additionally, offered knowledge does not support an augmented rate of spontaneous abortion among sub fertile women treated with Clomid for ovulation induction.

    6. Nursing Mothers

    It is not acknowledged whether or not Clomid is excreted in human milk. As several medications are excreted in human milk, caution ought to be exercised if Clomid is administered to a nursing woman. In some patients, clomid could scale back lactation.

    7. Ovarian Cancer

    Prolonged use of Clomid tablets could increase the chance of a borderline or invasive ovarian tumor.

    What are the Interactions of Clomid Tablet?

    All medicines interact differently and their effects vary from person to person. Go through the list of possible interactions when you take Clomid tablet with other medicines, disease, food or alcohol.

    • Interaction with Diseases: Interaction of Clomiphene tablets is unknown to diseases. Consult a doctor before starting the medicine and discuss the diseases for which currently you are taking medication. 
    • Interaction with the Alcohol: Interaction with alcohol is as well unknown. One should always contact a doctor and discuss the possible risks involved.
    • Interaction with Medicines: Interactions of Clomid tablet with other medicines may alter how the medications work or escalate the risk of some serious side effects. There are no known possible drug interactions. It is advised to keep a list of all the medicines you are currently taking (includes all prescribed, non-prescribed drugs as well as herbal products). Discuss it with your doctor. Do not change, start or stop any medicines dosage with doctor’s approval.

    Clomid is quite helpful in different cases of infertility, especially to induce ovulation. Yet it should be remembered that it has certain side effects and interactions due to which it comes under prescription drugs. Always make sure that it is consumed after approval of a registered practitioner only. To have more information on infertility issues or treatments like IVF and surrogacy, follow Elawoman or call at +917899912611.

    Dr. Smita Sanyal

    Written by

    MBBS, DGO, Infertility Certification, FImCH
    Laparoscopic Surgeon, Hysteroscopic Surgeon
    Gurgaon

    Dr. Smita Sanyal is an infertility specialist and hysteroscopy surgeon with rich years of experience. She is counted among the most sought-after gynaecologists in Gurugram. She has completed MBBS and DGO from Medical College, Calcutta in 1981 and 1984, respectively. She has also pursued Certificate course on Infertility And Endoscopy from Manchanda Endoscopy Institute in 2013. She is a member of the Delhi Society of Prenatal Diagnosis and Therapy, and Association of Obstetricians and Gynecologists of Delhi (AOGD) and Federation of Obstetrics and Gynecological Societies of India (FOGSI). Her areas of expertise are Normal Vaginal Delivery (NVD), Hysterectomy and Laparoscopic Surgery, High-Risk Pregnancy Care, Intrauterine Insemination (IUI). Dr. Smita Sanyal is an Intrauterine Insemination (IUI) specialist and currently associated with W Pratiksha Hospital in Gurgaon. You can get the contact details of Dr. Smita Sanyal at elawoman.com

    6 Comments

    user_img

    Himani Rathore

    My sister has taken clomid tablet on the recommendation of her gynecologist. I think this tablet is really helpful for inducing ovulation.

    Nov. 21, 2018, 11:41 a.m. 5.0

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    Rajani Bhadauria

    I have heard about these tablets but never knew in detail. Going to discuss it with my doctor about it and then start my medication.

    Nov. 17, 2018, 7:31 p.m. 4.5

    user_img

    Pushpa Gupta

    I had taken clomid tablet for ovulation and it worked it my case. My doctor had suggested to take it for proper ovulation.

    Nov. 15, 2018, 5:30 p.m. 4.5

    user_img

    Karnika Sachdev

    The interaction of alcohol with clomid is unknown. However, alcohol should be avoided when you are going through any kind of medication.

    Nov. 10, 2018, 3:51 p.m. 5.0

    user_img

    Harpreet

    There are also many side effects of clomid tablet. However, those are easily treated but then also one should take it only on doctor's consumption.

    Nov. 4, 2018, 12:28 p.m. 5.0

    user_img

    Kashvi Meherhomji

    My doctor has prescribed me Clomid 50 mg as I do not ovulate properly. I hope Clomid will correct my ovulatory cycle so that I can conceive a baby.

    Oct. 31, 2018, 6:30 p.m. 4.5

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