male fertility

Ibuprofen Linked to Male Infertility

  • 4.8 (7 Votes)

Ibuprofen is a nonsteroidal anti- inflammatory drug, which acts as a painkiller. If taken in large dosages it can lead to male infertility. Find out how to take precautions while consuming Ibuprofen and its usefulness for cases like osteoarthritis, rheumatoid arthritis, and fever.

Ibuprofen is a non-steroidal anti-inflammatory drug often consumed by athletes, Olympians in order to relieve pain and injuries. Ibuprofen is mostly sold without a prescription and has a negative impact on the testicles of young men. Intake of ibuprofen tablet should not exceed more than 3200 mg dose a day. Ibuprofen has several uses as well as side effects too. If Ibuprofen is consumed in large quantities, it can lead to male infertility problem. Male fertility can be assessed with the help of a semen analysis report, which tests the male seminal fluid on many parameters such as sperm count, mobility, morphology, liquefaction time etc.

male infertility issues

Ibuprofen can be consumed if a person is facing some common problems like:

  • Headache 
  • Dental Pain
  • Joint pain
  • Menstrual Cramps
  • Inflammatory disease in children and young adults
  • Muscles Aches
  • Rheumatoid Arthritis

It is also used when a person is suffers from persistent fever, flu and a common cold. Ibuprofen helps in reducing pain by blocking the natural substances produced in the body that cause inflammation. Blocking these substances, in turn, decreases swelling, pain, or fever in the body. However, if a person is undergoing some kind of treatment such as rheumatoid arthritis, it is necessary to consult a doctor before consuming Ibuprofen in case of pain or discomfort.

The Correct dosage of Ibuprofen

The dosages of Ibuprofen vary with the age of the individuals as well as the condition of the patient.

1. In case of osteoarthritis

If a person is suffering from osteoarthritis, they can have 1200 to 3000 mg/day of ibuprofen. They should not exceed its dosage more than 3200 mg/day. 

2. In case of rheumatoid arthritis

If a person is suffering from rheumatoid arthritis, 1200 to 3000 mg of Ibuprofen should be consumed per day. 

3. In case of joint pain and cramps

If a person is suffering from pain, they should take only 400 to 800 mg ibuprofen tablet at a time that too within a gap of 6 hours. Ibuprofen tablet can be given orally as well as intravenously. Once the symptoms subside, the person should stop consuming the medicine.


4. In case of a fever

In case of fever, one can consume 400 mg of ibuprofen four times a day within a gap of 6 hours for better results. In the later part of the course, a person can consume 100 mg, 200 mg and 400 mg orally or intravenously per day depending on the health of the individual. However, dosage should not be more than 3200 mg in a day.

Side Effects of Ibuprofen/ Symptoms of Ibuprofen

Ibuprofen can be related to a number of side effects if not taken according to prescription. Given below are some of the side effects of Ibuprofen:

  • Male Infertility
  • Rashes
  • Stomach Cramps
  • Kidney problem
  • Urgency in urinating
  • Heartburn and Dizziness
  • Visible water retention
  • Mood swings
  • Abdominal pain 
  • Ringing in the Ears 
  • Headache and Unusual tiredness 
  • Vomiting and Constipation 
  • Getting irritated or angry
  • Indigestion
  • Diarrhea

In severe cases, Ibuprofen can also have a negative impact on the following conditions:

  • a person’s vision
  • anemia levels
  • stomach ulcers
  • non-menstrual period bleeding 
  • blood in urine
  • canker stone
  • chest pain and heart failure

Besides male infertility, regular consumption of ibuprofen can lead to compensated hypogonadism, a rare condition that can lead to erectile dysfunction, depression, loss of muscle and bone mass. 

Impact of Ibuprofen on Male Infertility

According to research conducted in the US, it was found that the chances of male infertility levels were higher among men who consume Ibuprofen on a regular basis. Testicular problems were found to be common in men who consume more than 800 mg up to four times a day. Another study has concluded that Ibuprofen can have a potential impact on the pituitary glands. This has a negative effect on the production of testosterone that is the prime male hormone thereby affecting the sperm production. A disorder known as “Compensated Hypogonadism” is commonly seen in those individuals who consume Ibuprofen more than the recommended dosages.

ibuprofen impact male infertility

Factors That Can Cause Male Infertility

A number of factors can be responsible for male infertility. Some of the factors, which cause male infertility, are:

1. Sperm production problems:

Some men suffer from low sperm production problem, which can be due to chromosomal or genetic disorders, infections, varicocele, radiation damage, medicines and chemicals, torsions and undescended testes.

2. Erection and ejaculatory problems:

Some men can also have an erection or ejaculatory problems, a condition when a man finds it hard to maintain the erection of penis. It can be due to erectile dysfunction, infrequent intercourse, spinal cord injury, and damage to the nerves as well as the spinal cord.

3. Hormonal problems:

If the reproductive hormones of a male are not balanced well in the body, it can also result in male infertility. This can be caused due to anabolic steroid abuse, pituitary hormones problems or congenital lack of LH/FSH.

4. Sperm antibodies:

Sometimes, sperm antibodies occur in men due to procedures like vasectomy, injury or infection in the epidydimis of a man. Sperm antibodies have a negative impact on male fertility.

Prevention of Male Infertility While Using Ibuprofen

In order to prevent infertility while using ibuprofen, one can follow these steps:

1. Firstly, a person needs to reduce the level of consumption of Ibuprofen. A person should consume ibuprofen only in extreme conditions or if there is no alternative available for this type of medication.

2. Self-medication is extremely dangerous, so it is always advisable to consult the doctor if the need for ibuprofen arises.

3. A person must stick to the prescribed doses in order to avoid any kind of side effects associated with ibuprofen in future. In this way, one can effectively reduce the negative effects of Ibuprofen on the body.

affect male fertility levels

The effects of ibuprofen can be avoided if precaution is taken at the right time. Regular checkups are helpful to reduce male fertility levels. Even if Ibuprofen is designed to reduce pain or reduce bothersome inflammation, it is more likely to show indications of testicular related problems. Although male infertility is more common in older men, ibuprofen can negatively affect the pituitary gland among younger men too. The pituitary gland is directly responsible for the necessary production of sperm and testosterone in the male body. If you are required to take ibuprofen more than three days at a time, make sure you consult a doctor in advance for fertility- preserving and check if there is any other alternative available for pain management.

If you are looking for the best gynecologist in Delhi, can help you in your search. For complete information on normal delivery, IVF Treatment, Infertility Treatment, Surrogacy treatment, IUI Treatment you can consult Ela. Feel free to call on the given number for any inquiry or advice: +917899912611.

Dr. Kavita Jaggi Agrawal

About The Author

Infertility Specialist, Obstetrician Dr. Kavita Jaggi Agrawal

Dr. Kavita Jaggi Agrawal is an obstetrician, gynecologist and infertility specialist who is providing her valuable expertise in the field of gynecology and infertility issues. She ensures that the patients receive the required fertility treatments well on time. Dr. Kavita specializes in the treatments like High Risk Pregnancy Care, In Vitro Fertilization (IVF) and Reproductive Medicine. Currently, she is practicing at Amit Jaggi Memorial Hospital, Vibhav Nagar, Agra.



Shewta Roy

Thanks for sharing this. I usually have rashes after having this medicine.

Oct. 10, 2018, 5:26 p.m. 4.5


Sangeeta Rawat

I take nicip plus for fever. It is a better medicine.

Oct. 3, 2018, 3:24 p.m. 5.0


Keshav Jha

Meftal is better painkiller than ibuprofen. They work better without any side-effects. Intake should be limited as per requirement.

Sept. 1, 2018, 9:22 p.m. 4.5


Shushant Kapoor

Please suggest some replacement for ibuprofen without any side-effects, as I have back pain and painkillers are always a need for me.

Aug. 12, 2018, 3:19 p.m. 5.0


Ellen Bratt

Thanks for sharing this! I have been using this medicine since so long without knowing its side-effects.

June 25, 2018, 5:16 p.m. 5.0


Priscilla Anderson

Never observed a direct connection between Ibuprofen and male infertility prior to this.

June 4, 2018, 4:59 p.m. 5.0


K P Patil

Even medicines can be this much harmful these days.

May 9, 2018, 7:01 a.m. 4.5

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