in vitro fertilisation (ivf)

IVF Cycle - Know the reasons of IVF Failure and Some Common Lifestyle Disorders

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  • 4.7   (6 Votes)
Medically Reviewed by Dr. Deepika Tiwari - MBBS on 26 Feb 2019 - Written by Dr. Neeta Gupta - MBBS - Grammatically Approved by Dr. Kavita Jaggi Agrawal - MBBS

Reasons of IVF failure such as hormonal problems, implantation failures, flawed embryos, chromosomal abnormalities. Improper lifestyle problems include obesity, imbalanced diet, stressful lifestyle. IVF failure causes need to be dealt in a proper manner to avoid IVF cycle failure.

Surrogacy is an assisted reproduction-based procedure of IVF treatments where the intended performed for infertile parents who want to have a child who is genetically related parents engage a surrogate for the gestation and birth. Gestational surrogates carry the prepared embryo with the mother or donor’s egg and father or donor’s sperm. Surrogacy comprises a valid option for a variety of medical conditions or circumstances ranging from medical to social reasons.

Let’s discuss in detail what can be the reasons for IVF Failure in Surrogacy:

  • Why IVF fails in surrogacy?
  • What are the ways to deal with a failed IVF cycle in surrogacy?

Reasons of IVF Failure in Surrogacy

Possible reasons for having a failed IVF cycle in surrogacy procedure can be:

1) Flawed Embryos:  Flawed embryos takes place mostly due to wrong number of chromosomes. An embryo transfer performed with the correct number of chromosomes can raise the success rates to as high as to 50 - 60 percent. Flawed embryos do not implant into uterus. When embryos are not able to grow enough it is more likely that they die out. Age has a significant role to play in the development of wrong chromosomes. In cases, where women have crossed the age of 40 years or more conception after embryo implantation is possible but usually ends up in miscarriage.

2) Sperm Quality:  Semen analysis is conducted because in many cases sperm source is the cause for IVF failure. It happens when there is a defect with the DNA carried in the sperm that can cause an IVF cycle to fail.

3) Body's Hormonal Response for IVF Surrogacy:  Women having stronger hormonal balance are more likely to have a successful IVF cycle in comparison to the women whose hormonal systems are less healthy. Women with higher Follicle Stimulating Hormone (FSH) respond slowly to fertility medications. Also, with a higher age of female partner, fertility decreases and thus results in decreased egg production. Lower production of eggs can result in improper screening of the eggs and potential implantation.

4) Ovarian Hyperstimulation Syndrome (OHSS):  This condition can occur in some women during IVF due to injectable hormone medications that are used to stimulate follicles containing eggs. It causes the ovaries to become inflamed and painful resulting in ending of an IVF cycle.

5) Chromosomal Abnormalities:  Chromosomal abnormalities are a general cause of aborted fertility cycles whether in natural conception or IVF. Chromosomes play an important role in the conception both naturally or artificially. It is believed that with the advancement of age chromosomal abnormalities in the eggs of a woman increases in comparison to men. This can be the reason why women are said to grow older at a faster rate in comparison to men.

6) Endometrial Lining:  Endometrial lining receptivity also plays a vital role in failed embryo transfer. The intended mother or surrogate is usually given medication for preparation of the uterus and is monitored in the weeks prior to the transfer. A thin endometrial is encountered infrequently (2.4%) in IVF cycles. The etiology of thin endometrial plays a significant part in endometrial receptivity.

7) Implantation Failure:  The cause for IVF failure can also occur when the process is in its concluding stage, during the implantation. The gametes may both seem to be healthy, but polyps, poor blood flow, cysts and a thin uterine lining can lead to a failed implantation of the embryo.

Ways to Deal with a Failed IVF Cycle in Surrogacy

Now, as the causes of the failure of IVF cycle are known, it is also equally important that you get to know regarding the ways to deal with IVF cycle failure in surrogacy and proceed with it accordingly.

  • Preimplantation Genetic Diagnosis:  Preimplantation Genetic Diagnosis (PGD) is a reproductive technology which is used in cases related to repeated failures. PGD test is done to screen and find out the genetic disorders which have higher chances of passing on to the fetus. If the embryos are not genetically fit, then new embryos can be formed from the donor egg or donor sperm.
  • Try more than one IVF cycle:  It is always recommended that the couples need to make sure that they try at least thrice before giving up with the trials of the IVF cycle. According to research, it has been found that the IVF success chances improve with a number of cycles performed. The utilization of the extra embryos helps in increasing success rates.
  • Sperm Fragmentation Test:  If a couple has a doubt about the presence of genetic abnormalities in the sperms then test like Sperm Fragmentation Test is advised for the male partner. This is an advanced test where the amount of damage to the chromosomes is found out which further helps a couple to proceed effectively in a right way. If male’s sperm sample is not fit for IVF, then donor sperm can be used.
  • Opting for donor egg: If the quality of eggs of the intended mother is not good, then obviously going with donor egg is the best choice.
  • Frozen Embryo Transfer procedure (FET):  If the surrogate mother has a failed IVF cycle with fresh embryo transfer, she is advised to undergo Frozen Embryo Transfer in her next cycle. Chances of IVF are good with Frozen Embryo Transfer.
  • Transferring more than one embryo:  The infertility specialist will choose to transfer more than 2 embryos after discussing with the patient so that at least one embryo can be successfully implanted thus turning into success. Yet it can also result in multiple pregnancies such as twins or triplets.
  • Reanalyze the quality of eggs:  If the PGD results show the genetic defect in the embryo then either the sperms or eggs (in rare cases both) are responsible for it. These gametes are tested individually for their quality before forming embryos again. The infertility specialist checks the quality of the stored or freshly retrieved eggs, which boosts the chances of getting positive pregnancy news.

To learn more about growing your family with the help of IVF surrogacy and about other infertility treatments, feel free to visit elawoman.com or talk to our fertility experts at +91-7899912611.

References:

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691969/
  2. https://www.reproductivefacts.org/news-and-publications/patient-fact-sheets-and-booklets/documents/fact-sheets-and-info-booklets/third-party-reproduction-sperm-egg-and-embryo-donation-and-surrogacy/
  3. https://www.conceiveabilities.com/about/blog/reasons-for-an-unsuccessful-egg-donor-cycle

Dr. Neeta Gupta

Written by

Infertility Specialist, IVF Specialist
Noida

Dr. Neeta Gupta is a famous infertility specialist in Noida having an overall experience of more than 2 decades of experience in the field of gynecology and infertility medicine. She did her MBBS from Madurai Medical College in the year 2000. Then, she completed MD in Obstetrics and Gynecology from Pt. BD Sharma Institute of Medical Sciences, Rohtak in the year 2002. Later, she pursued MRCOG from Royal College of Obstetrics and Gynecologists in 2006. She also received Post Doctoral Fellowship in Reproductive Medicine from CIMAR Edappal in 2013. Dr. Neeta has appreciating experience in Infertility Evaluation / Treatments, High-Risk Pregnancy Care, Laparoscopic Surgery and PCOD Treatment. She is currently practicing at Sneh Child and Infertility Clinic, Noida. She also practises at Fortis Hospital, Noida.

6 Comments

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Nidhi Rajawat

Sometimes there are no explanations for why your IVF cycle got failed. I have experienced it as my first IVF cycle got failed and there was no reason for it. I think it differs from person to person that how your body responds to a particular treatment.

Nov. 24, 2018, 1:54 p.m. 4.5

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Swati Arora

I started doing regular exercises to stay physically fit for IVF treatment. It really helped me in having my treatment successful.

Nov. 21, 2018, 10:05 a.m. 5.0

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Rituparno Das

The weight of the intended mother plays a very important role in the success of the IVF. When my sister was pregnant her doctor warned her about her weight issue. She did not take it seriously. Her treatment failed later on.

Nov. 17, 2018, 7:44 p.m. 5.0

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Shweta Pandey

I have experienced two failed IVF cycles, after that the third one was finally successful. It is not necessary that you will get success in your first attempt and there can be many reasons for the failure of the cycle.

Nov. 10, 2018, 9:35 a.m. 4.5

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Shalini Awasthi

I lost my baby because of being an alcoholic. So, the doctor suggested me to stop drinking to have a successful treatment next time.

Nov. 7, 2018, 3:48 p.m. 4.5

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Upendra Sivasubramaniam

Our 2 IVF cycles got failed and then we chose PGD for our next cycle. After PGD results, we got to know that our embryos have a genetic problem due to which our IVF failed twice. To proceed with, we opted egg donor this time and our IVF was successful.

Oct. 31, 2018, 12:26 p.m. 4.5

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