Motherhood is a blissful experience no matter the challenges every woman has to go through. This is the reason, IVF treatment or IVF procedure has become a boon for the couples who cannot conceive. But in some cases, there are repeated IVF failures.
1. Common causes of repeated IVF failures:
a- Uterine abnormalities: Previously diagnosed or untreated abnormalities like uterine fibroid/endometrial polyps/septum, etc. can be a cause for implantation failures.
b- Poor endometrium:Thin endometrium or poor quality endometrium i.e endometrium with poor receptivity will not be suitable for implantation.
c- Embryo quality: Chromosomally abnormal embryos or poor quality embryos will face difficulty in implantation, and even if they can, they may not stay for a long time. When the Zona, an embryonic layer present around the oocyte, is thicker than usual, it has been associated with implantation failures, due to the failure of the zona to rupture during fertilization.
d- Genetic abnormalities in the gametes: Any defect, even minor ones such as chromosomal microdeletions can compromise the quality of the gamete and thus embryo.
e- Autoimmune diseases: If you are suffering from autoimmune diseases, you might be at risk of recurrent IVF failures. Usually, screening is done in patients with repeated pregnancy losses to rule out Anti-Phospholipid Antibody syndrome, an autoimmune disease.
g- Difficulty in embryo transfer: One common cause of failed IVF treatment or IVF procedure failure is the embryo transfer. Problems during embryo transfer or blood seen at catheter tips indicate a high chance of failure in thisinfertility treatment.
h- Suboptimal stimulation of the ovaries: This also increases your risk of repeat IVF treatment or IVF procedure failure due to the inability in the production of eggs for fertilization.
i- Age:Not every teenager or young women will always have regular, ovulatory cycles. Hence to deem such a person as infertile would be incorrect. Sadly, we still encounter women who have been married at an early age and bear the pressure to conceive, although their hypothalamic-pituitary-ovarian axis is not yet stable. And women above 35 years, start experiencing a drastic change in their hormonal levels after infertility treatment.
j- Weight: Don’t just rule out that being overweight causes a high risk of IVF procedure or IVF treatment failure. As women who are underweight can also experience repeated IVF failure.
k- Overweight/ Obese: The women need assistance with conception because they mainly suffer from PCOS symptoms due to ovulation, or often have miscarriages and higher chances of missed abortions. The hormonal changes lead to being androgenic, which in turn causes poor quality eggs and thus, poor embryos through IVF treatment or IVF procedure.
l- Underweight/anorexic: Women who are underweight/anorexic/athletes/those doing strenuous exercises, often fail to ovulate due to the decrease in the hormone estrogen. This might lead to absent or irregular periods. Some may present as a variation of Polycystic ovaries.
2. Prevent repeated IVF failures:
a- The first thing that must be done is a thorough examination including blood tests and ultrasound. The latter two will especially aid in determining the ovarian reserve.
b- Thereafter, a laparoscopic hysteroscopy exam must be done to look for and deal with any physical obstacles to conception.
c- Freshening of the poor quality endometrium is also to be done at this time. And more importantly, a sample should be sent to rule out tuberculosis.
d- Hydrosalpinges can be clipped at this time to prevent the embryotoxic fluid from causing IVF failures.
e- Following all this, the correct protocol for ovarian stimulation must be chosen and started.
f- However, care should be taken that the endometrium is fit for implantation quality and thickness. If not, then it must be supplemented with estrogen till it becomes thick and ready for the implantation and thereafter, in some cases.
g- Some patients may be given granulocyte-colony stimulating factor injection either intrauterine or subcutaneous, prior to ovum pick up. In women with repeated IVF failure, IV immunoglobulin G when given prior to embryo transfer greatly aids in implantation.
3. What can a physician do: The physician can greatly help in this matter by:
a- Dealing with the pre-existing morbidities in the woman such as thyroid disorders
b- Obtaining the correct BMI to improve chances of conception via IVF treatment or IVF procedure.
Laparoscopy a type of Minimally Invasive Surgery (MIS), is a surgical diagnostic or therapeutic procedure that is used to examine the organs inside the abdomen especially the female reproductive system with an aid of a camera. It is advantageous over traditional open surgery as it allows rapid recovery, less pain, smaller scars and a much lesser hospital stay compared to a normal Surgery.
The cost of IUI treatment in Lucknow varies from Rs. 8,600 to Rs.34,000 including the expenses of medications and disposables. IUI procedure cost usually varies with the experience of the doctor and amount of medications required. Welcare Hospital and Javitri Hospital provide IUI treatment at affordable costs.
With modern advances in Medical treatments, donor eggs are being used with no negative impact for a successful ART treatment in case of couples. The success rates of IVF treatment with donor eggs increases to even more than 75% which is much higher as compared to self egg IVF of 41%.Even the success rate for surrogacy treatments increase to more than 95% with donor eggs.
IVF treatment involves the usage of IVF injections and medications for multiple egg growth and development. But these IVF injections might lead to some side effects including higher risks of multiple births, blurred vision, hot flashes, changes in cervical mucus, increased chances of ovarian hyper stimulation and ectopic pregnancies.
Artificial insemination is a procedure, which involves a series of steps followed by a female trying to have a baby. It including steps such as collecting semen in a jar, waiting for the semen to liquefy, loading of semen into the syringe after liquefaction, inserting the syringe into the uterus and releasing the semen out of it into the uterus.
IVF procedure takes around 6-8weeks from start to finish. The week 1 involves basic consultation and diagnosis. Week 2 to Week 4 involvesregularization of cycles and suppression of ovaries.Week 5 and 6 involves consumption of fertility medications to stimulate ovaries and for monitoring visits. Week 7 includes egg retrieval, fertilization and transfer of embryos.
Total Cost for Laparoscopic surgery varies between Rs. 33,500 to Rs. 44,200 depending upon the clinic or the extent of corrective treatment required during the procedure. Laparoscopic surgery takes from 20 minutes to 2 hours depending on the criticality of the treatment. Laparoscopic surgery is majorly used to treat problems of the female reproductive organs.
IUI (intra uterine procedure) is a fertility procedure, which involves the insertion of sperms into the uterus to fertilize the eggs. IUI treatments are not painful as all. But it may lead to mild abdominal cramps or discomfort during the procedure. If IUI is medicine assisted, then one may experience side effects of fertility drugs such as nausea or vomiting.
Male infertility can be diagnosed successfully with the help of a procedure called semen analysis. Semen analysis test includes evaluating the semen characteristics on many parameters including semen volume, sperm count, sperm motility, progression, pH value, sperm morphology, fructose level and liquefaction time.
Sperm donation is a process in which a man donates his sperms to be used in the artificial insemination of a female who is not his sexual partner. In India, Sperm donors are paid between Rs. 500 to Rs. 2,000 depending on the physical features, built, sperm health as well as qualifications of the respective sperm donor.
Find the list of best IUI Centres in Lucknow along with their ratings, success rates, services, IUI package cost as well as location of best centres. Welcare Hospital and Sarthak Test Tube Baby Center rank among the top IUI Centres in Lucknow because of their low treatment costs and high success rates.
Top things that can better your chances of getting pregnant after i...