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Procedure, Benefits and Setbacks of Sequential Embryo Transfer (SET)

  • 4.8 (6 Votes)
  • 144456 views

In Sequential embryo transfer (SET), two sets of embryos are transferred to the womans womb on different days in one menstrual cycle. It is one of the effective methods of increasing the chances of pregnancy and implantation rates in infertile couples. But there is a risk of miscarriage and multiple pregnancies. It is a very popular method done along with IVF nowadays.

One of the much-talked procedures, while one plans for IVF, is SET (Sequential Embryo Transfer). It has become a worldwide trend along with its strong foothold in India. But what it is? Why is it beneficial? Does this have a side effect on your regular IVF cycle? Browse the article to get all the answers.

What is Sequential Embryo Transfer?

Sequential Embryo Transfer is a common and popular technique used in In-Vitro Fertilization (IVF). In this technique, solid and created embryos are transferred twice to the mother’s womb, on day 2-3 and day 5-6; whichever is considered the best by your embryologist.

This is done to guarantee that the best and quality embryos get implanted in the uterus through the natural process of implantation.

Procedure for Sequential Embryo Transfer

  • Under this procedure of Sequential Embryo Transfer (SET), two sets of embryos (day 2/3 and day 5/6) are transferred to a woman’s womb within one menstrual cycle.
  • The very first group of embryos consists the rapidly growing embryos with good quality, which get transferred to the womb after 2-3 days of their formation.
  • After this first batch transfer, the second group of embryos (5/6 days of life) is transferred to the uterus within a few days.

Also, learn about the Embryo transfer procedure utilized during conventional IVF procedure.

  • This second group of embryos is more mature than the first group and almost reaches the Blastocyst stage of their development.
  • Normally, this sequencing is done to fetch more and more chances of conception.
  • As the second group of embryos is more advanced (Embryo development stages), they hold the extra advantage of attaching themselves easily to the uterine wall.
  • This treatment is beneficial as the first group of embryos releases a hormone called 'cytokines' which replenishes the uterus and prepares the ground for better implantation.
  • After one or more embryos are implanted, the extra embryos are cryopreserved for future fertility.

sequential embryo transfer

Is Sequential Embryo Transfer a really good idea?

SET or Sequential Embryo Transfer with IVF procedure demands for an extra cost. Also, as it is not a medically guaranteed procedure, it might not always help you in getting the desired result. The chances of IVF success through SET mostly lie between 30-40%. Also, you cannot trust all the IVF clinics or doctors, as not everyone is equally competent in carrying out SET procedure with a guarantee. Moreover, it is a risky procedure, which might lead to multiple pregnancies and unexpected miscarriages.

Normally, from the patient’s point of view, SET seems to be a great idea as they are getting the best of both the sets of transfer. Usually, a patient is happy after the first batch of transfer only as they consider that the best will survive. However, as the later set of embryos are sent after the Blastocyst stage, they may harm the first set of embryos along with damaging themselves inside the uterus causing miscarriages and added trouble.

However, not all SETs turn into a mistake and there are a huge number of success rates of IVF with SET procedure. It just takes an effort to get two or three good quality blastocysts rather than transferring them in bulk to fetch better chances.

Is sequential embryo transfer for me?

Sequential embryo transfer technology can be beneficial for you if you have suffered repeated implantation failures. The technique is known to increase the rate of implantation so you may discuss with your physician if they find you as an eligible candidate for it.

Essential tips for the success of embryo transfer

Embryo transfer is an important step in IVF treatment and although it is performed by the doctor and depends mostly upon their competence, you can do your part in making it a success by:

1. Carefully select your doctor:

Know that it is primarily the expertise and experience of the doctor on which the success of the IVF cycle depends. Make sure that you are in the right hands and under the care of the most experienced doctors to keep relaxed during the process.

carefully select your doctor

2. Get multiple embryos transferred if you are above 40 years:

For women above the age of 40 years, it is advisable to have more than one embryo transferred at a time because of the fact that the implantation rate drops down after 35 years of age hence number of embryos being picked up means better chances of success.

3. Take care of what you eat:

Eat as much healthy as you can with all the nutrients included in your meals. Have a diet that has vegetables, fiber, fruits and nuts in it. You do not have to essentially go after any specific diet plan while all you need is a healthy balanced diet.

4. Folic acid and vitamin supplements are a must:

Folic acid, along with multivitamins, is usually advised by gynecologists to women for a minimum of three months prior to the beginning of the IVF treatment. It is said to be crucial in reducing birth defects and can be taken along with other multivitamins with vitamin D and rest of the B vitamins.

5. Stay active:

Staying in the bed right after the implantation may not be a good idea at all. Rather being physically active and going for walks can be beneficial for implantation.

How long does the process of embryo transfer take?

It would not take more than five minutes for this process to take place. Once the procedure is completed you are expected to lie down for another five minutes and a short briefing of the important instructions given before allowing to go home. However, you should be mindful of the fact that during sequential embryo transfer, there is more than one embryo being transferred into the uterus hence the time can be a little more as compared to a single embryo transfer.

process of embryo transfer taking

How long does it take to get pregnant after embryo transfer?

Usually, during a natural pregnancy, it can take around six days time for the fertilization between egg and sperm to form a zygote and then subsequently an embryo. This embryo can further take 6 to 10 days to get successfully implanted in the uterus. If we talk about an IVF cycle, it can take up to 5 days for the embryo to get implanted and pregnancy to begin after the embryo transfer is done.

What are the possible setbacks of sequential embryo transfer?

Since blastocysts with high implantation potential are used in the process, all the embryos may end up getting successfully implanted in the uterus giving way to multiple pregnancies. So women undergoing this procedure are at higher chances of having more than one baby in a single pregnancy.

Any normal or healthy remaining embryos after IVF treatment or test tube baby may also be frozen for implantation at a later time. Read more about Embryo Freezing at Elawoman Fertility blog.

Dr. Surveen Ghumman

About The Author

Infertility Specialist, Obstetrician Dr. Surveen Ghumman
Delhi

Dr. Surveen Ghumman is an infertility specialist and gynecologist specializing in IVF, Reproductive Endocrinology, Recurrent failures of implantation, Embryology, Fertility preservation and Surrogacy. Dr. Surveen has completed MBBS from Christian Medical College, Ludhiana in 1986 and MD in Obstetrics and Gynecology from Government Medical College, Amritsar in 1991. She has also pursued certificate courses in ART and Clinical Embryology from Manipal University and fellowships in Minimal Access Surgeries. She has also pursued Micromanipulation in ART in the year 2011. Dr. Surveen is practicing at The Fertility Clinic IVF Solutions and Max Super Specialty Hospital. For more information, visit elawoman.com

SOURCES AND REFERENCES:

  1. What to do if a surrogate mother has failed ivf cycle? IVF cycle, Elawoman - 2018
  2. What is in-vitro fertilization (ivf) and its needs IVF, Elawoman - 2017
  3. Symptoms of implantation after iui implantation, Elawoman - 2018
  4. All you need to know about embryo freezing embryos, Elawoman - 2017
  5. What are the functions of uterus? uterus, Elawoman - 2017
  6. Embryo transfer procedure in ivf Embryo transfer procedure, Elawoman - 2017
  7. Embryo development stages Embryo development stages, Elawoman - 2017
  8. Ivf procedure in six steps IVF procedure, Elawoman - 2017
  9. Six factors determine ivf success rate chances of IVF success, Elawoman - 2017
  10. 6 best ivf hospitals in delhi IVF clinics, Elawoman - 2018

6 Comments

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Meera Jaiswal

Thanks for sharing this, I am having SET treatment and I will follow the tipping points in this article.

Oct. 3, 2018, 9:43 p.m. 5.0

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Noila Pratt

Please suggest where to find the best sequential embryos transfer doctor? Ela please help!

Oct. 1, 2018, 3:11 a.m. 4.5

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Bani Pratap

After 2 embryos transfer, I am still not pregnant. What should I do now?

Sept. 30, 2018, 6:55 p.m. 4.5

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Ayushi Negi

I think sequential embryo transfer is a new practice. I doubt whether it is practised in India or not.

Sept. 26, 2018, 9:52 a.m. 5.0

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Zain Ansari

Sequential embryos transfer is a highly successful method so, don't bother about any money wasting as you are going to have positive results.

Sept. 13, 2018, 5:24 p.m. 5.0

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Tamkinat Nahid

Sept. 7, 2018, 11:32 a.m. 4.5

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