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06 February 2017

IMSI Is A Solution To Male Infertility

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Written by Dr. R K Sharma
IMSI may improve the chances of ivf treatmnet or ivf procedure and can be used if you after several unsuccessful test tube baby attempts or IVF treatment failure

IMSI may improve the chances of ivf treatmnet or ivf procedure and can be used if you after several unsuccessful test tube baby attempts or IVF treatment failure

Introduced in 2001, Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) represents a more sophisticated way of ICSI whereby, prior to injection, the spermatozoon is chosen at higher magnification. Doing as such, the spermatozoon can be evaluated for the fine integrity of its nucleus and the injection of a normal spermatozoon with a vacuole-free head can be guaranteed. IMSI (Intracytoplasmic morphologically-selected sperm injection) is a laboratory technique used in IVF treatments (IVF) or IVF procedures that involves inserting sperm into the egg. IMSI technique is used in test tube baby procedure. 

Intracytoplasmic morphologically selected sperm injection (IMSI) is still proposed and utilized in the clinical practice to enhance the reproductive outcome in infertile couples who are facing infertility problems are scheduled for conventional intracytoplasmic sperm injection (ICSI). IMSI (Intracytoplasmic morphologically-selected sperm injection) is a laboratory technique used in IVF treatments (IVF) or IVF procedures that involves inserting sperm into the egg. IMSI technique is used in test tube baby procedure. 

One part of male infertility which can be assessed is the level of abnormalities present in the sperm. Such abnormalities result in poorer quality sperm which in turn dimish the possibility of fertilization of an egg. They have also been shown to influence the hereditary makeup of an embryo which in turn could lead to miscarriage.

Numerous sperm abnormalities can be identified by the embryologist using a normal microscope lens with magnification 400-600x. IMSI (Intracytoplasmic morphologically-selected sperm injection) is a laboratory technique used in IVF treatments (IVF) or IVF procedures that involves inserting sperm into the egg. IMSI technique is used in test tube baby procedure. This is utilized when ICSI treatment is performed. Selecting sperm using IMSI can help to dimish the possibility of injecting a sperm with damaged DNA into the egg.

Who can go for the IMSI infertility treatment?

  1. Male partners over 40 years
  2. Patients for whom the semen analysis has identified a high number of abnormally formed sperm
  3. Patients that have not achieved good quality embryos in previous cycles (if not related to egg quality)
  4. Patients with a history of miscarriages
  5. Two failed ICSI Cycles (Failed cycles constitutes no pregnancy or first-trimester miscarriage)
  6. Three failed IVF cycles
  7. Over 90% abnormal forms in sperm (LFC SA not TDL)

What is the treatment procedure of IMSI?

  1. Selection: A preliminary selection of sperm is carried out under a microscope 15 times more powerful than usual.
  2. With this microscope, we can see the internal morphology of the sperm and discard those with abnormalities. According to the, WHO a mature sperm should ideally have an oval head shape that is 4-5 microns long and 2.5-3.5 microns wide.
  3. Through intracytoplasmic sperm injection, a sperm is injected into each egg.
  4. Transfer: 1 to 3 spermatozoa is selected and placed in a thin catheter and then inserted deep inside the uterus by the gynecologist.

The Intra Cytoplasmic Sperm Injection selected, better known as IMSI (Intracytoplasmic morphologically selected sperm injection) is a lab technique used in IVF treatments (IVF) and involves inserting sperm into the egg.

IMSI is a real-time method where sperm is selected before the microinjection takes place in the patient. This is done using an inverted microscope of very high power that is- magnifying power (around 6000 times) than that normally used in reproductive laboratories (400 times) to carry out ICSI or infertility treatments. IMSI (Intracytoplasmic morphologically-selected sperm injection) is a laboratory technique used in IVF treatments (IVF) or IVF procedures that involves inserting sperm into the egg. IMSI technique is used in test tube baby procedure. 

With this microscope, Biologists can see the internal morphology of sperm and discard those with abnormalities successfully. IMSI may improve the chances of fertilization in vitro (IVF) and can be used if you have performed several unsuccessful In Vitro Fertilization (IVF) attempts.

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