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    fertility basics

    What is Clomid and How does it Result in Twins or Multiple Births?

    • 4.8   (6 Votes)
    Medically Reviewed by Dr. Deepika Tiwari - MS, MBBS on 14 Sep 2018 - Written by Dr. Kavita Jaggi Agrawal - MS, MBBS - Grammatically Approved by Dr. Sailaja Vuppu - MBBS, CCT, MRCOG

    Clomid Tablet is used to stimulate ovaries. Clomid tablets can result in twins or multiple births as intake of clomid results in the over production of egg stimulating hormones, which further causes, the release of more than 1 egg from the ovary. The side effects of clomid tablet are breast pain, headache, mood swings, nausea.

    It is a question of general curiosity whether Clomid can result in multiple births, or can women actually get pregnant with twins, triplets or more using Clomid drug? Well, the answer to this question is YES, but the chances of multiple births depend on few factors like age, height, weight, sexual habits etc.

    This article will enlighten you about the chances of having twins while being on Clomid drug, how it does it and what to expect with a twin pregnancy that happens due to Clomid.

    What is Clomid?

    Clomid, generally known as Clomiphene citrate, is a fertility drug used to stimulate eggs that are developed and released from the ovaries. This drug is given under proper supervision after all the necessary fertility tests are performed to see if infertility experienced by the woman is due to the lack of ovulation or not. 
    Infertility can be due to a number of reasons. Some of the common reasons include:

    • Medical history, including any surgeries
    • Your medication
    • Intake or use of caffeine, alcohol, cigarettes or drugs
    • Your sexual habits, how often you have sex, or any other sexual problems of disease

    clomid tablet

    A woman experiencing infertility can increase their chances of getting pregnant with the use of Clomid drug. The female reproductive system works via a complex feedback system. Well as clinically tested, there is no assurance that it will definitely lead to multiple childbirths. It may or may not be. Clomid causes twin pregnancies between 5 and 8 percent of the time. Odds of conceiving triplets or more with the consumption of Clomid tablet are lower than one percent. 
    Now you might be thinking if you have twins with clomid will they be identical or not? Well the twins conceived with the help of this drug can be identical or fraternal but the chances of being identical are very less than being fraternal. 

    When taking Clomid, multiple pregnancy rates are quite higher than natural multiple conception rates. In normally conceived pregnancies, the percentage of women who conceive twins is 1.2 percent. In Clomid conceived pregnancies, the percentage of women who conceive twins is 5 to 10 percent. 

    Now as everything have its pros and cons. Same way this drug has its side effects too. This drug may cause side effects running from mild to serious. If it is serious, they should be reported to the doctor immediately.

    Mild side effects of Clomid include:

    • Flushing or feeling warm
    • Nauseous stomach 
    • Throwing up
    • Breast pain
    • Headache 
    • Spotting
    • Mood swings

    Serious effects of Clomid Drug include:

    Why Clomid can lead to twins?

    There are innumerable numbers of follicles present in a woman’s ovaries that contain eggs. These follicles mature with time and release a single egg during every menstrual cycle. It is a slow process and just one egg gets matured every month. Once the egg, in any of the ovaries, is fully matured in a dominant follicle, it sends out hormonal signals to the brain through the bloodstream to lower down the production of egg-stimulating hormones.

    clomid can lead twins

    Clomid can trick the brain by telling it to constantly produce egg-stimulating hormones. The increased supply of these hormones hence leads to the growth and development of more number of follicles in the ovaries. This is how the chances of more than one number of eggs are established during a single cycle. 
    It can straightaway lead to the fertilization of more than one egg to form 2 or more embryos.

    Are Clomid Twins Identical?

    Well, No. Most of the times twins that take birth as a result of clomid are not identical and the probability of this is as low as one in five. The reason being that twins come from two separate eggs which is the case of almost 80 percent of fraternal twin pregnancies arising from Clomid.

    The reason behind the formation of identical twins or Siamese twins is that they originate when two sperms fertilize one egg. Whereas taking clomid, you produce more eggs because of which there could be two eggs released from the ovaries during a single cycle.

    Other Factors That Up to the Odds Having Twins

    Not just Clomid but there are others contributing factors that can lead you to a pregnancy with twins. These factors can be listed as 

    • Weight
    • Age
    • Height
    • Family history

    It is interesting to know that the higher dosage of Clomid can increase the chances of having twins, on the contrary, it can also lead to no pregnancy at all. The reason is that high amounts of Clomid in the blood can result in the thickening of cervical mucus thereby making it hard for the sperms to travel. This is the only reason why doctors avoid heavy doses of the drug in the beginning of the treatment and only increase it if ovulation does not occur.

    Apart from this, women who do not face any issues with ovulation or the ones younger than the age of 25 years are at increased chances of having twins with Clomid.

    How to Know if it is a Twin Pregnancy After Clomid?

    Knowing about a twin pregnancy is difficult due to the fact that one doesn’t get any different symptoms even if there are two babies in the womb. You cannot even expect the hCG hormone levels to be any higher than the normal and getting an early pregnancy positive test can also be not taken as an indicator of a twin pregnancy. It simply means that you wouldn’t know about a twin pregnancy before an ultrasound shows two gestational sacs. Although your doctor may ask for a scan two weeks after missing period yet it is quite early to get a confirmation on a twin pregnancy. It is during the eighth week that a twin pregnancy can be clearly detected with a scan.

    What to do if You Conceive Twins with Clomid?

    You don’t really have to worry even if you conceive twins after using Clomid. Good prenatal care is all that is required to have a happy twin pregnancy without any complications.

    • It is not at all necessary that your pregnancy would fall under high-risk category yet you might have to visit an OB/Gyne regularly. 
    • If your doctor feels that there are complications then you would be referred to a specialist. Those using Clomid are most likely to be suffering from infertility and such women are always at an elevated risk of preterm birth.
    • Due to these reasons, the doctor would like to monitor a twin pregnancy more closely as compared to a single one. Every aspect of the pregnancy is followed up just to see if the twins are sharing placenta or sac.

    So as discussed above, there are higher chances of conceiving twins using Clomid as put against conceiving normally. If you are actually experiencing infertility or trying to conceive for a long time or even wanting to conceive twins, there is a good chance that this drug will help you have one. 
    I hope this article helped you to know all that you wanted to know about Clomid. You can read more about it at

    Dr. Kavita Jaggi Agrawal

    Written by

    MS, MBBS
    Obstetrician, Infertility Specialist
    Dr. Kavita Jaggi Agrawal is an obstetrician, gynecologist and infertility specialist who is providing her valuable expertise in the field of gynecology and infertility issues. She ensures that the patients receive the required fertility treatments well on time. Dr. Kavita specializes in the treatments like High Risk Pregnancy Care, In Vitro Fertilization (IVF) and Reproductive Medicine. Currently, she is practicing at Amit Jaggi Memorial Hospital, Vibhav Nagar, Agra.


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    Pari Lata

    I am pregnant with twins and I am too worried about the health of my babies. Does Clomid users deliver healthy babies or one healthier and another not?

    Oct. 11, 2018, 9:07 a.m. 5.0


    Deepak Ranjan

    Do Letrozole tablets also posses the chances of having twins? Letrozole and Clomid both stimulate ovulation in women. Please suggest!

    Oct. 1, 2018, 9:18 p.m. 4.5


    Mandini Singla

    I am having Clomid treatment as I have PCOS, let's see if I have twins or not.

    Sept. 30, 2018, 11:34 a.m. 4.5


    Sarita Baxi

    Thanks for sharing this article. It was really helpful to make my mind before having them.

    Sept. 30, 2018, 5:59 a.m. 5.0


    Gyatri Sinha

    Is it possible to have Clomid tablets without having PCOS? Or it can cause any side-effects?

    Sept. 14, 2018, 10:53 a.m. 5.0


    Thayanban Purva

    Sept. 13, 2018, 12:20 p.m. 4.5

    View all comments

    Leave a Comment



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