fertility basics

About Unexplained Infertility And Its Treatment

  • 4.8 (5 Votes)

Female and male infertility issues are common these days and can be treated with fertility treatments. Unexplained fertility can affect your chances of conceiving

Unexplained infertility is a very common term we hear in the reproductive world. Unexplained infertility is the term used when there is no proven or found cause for infertility in men and women. Commonly happens that the couple goes through all of the infertility tests available and everything comes back clear. This is of course a good news but can be so frustrating at times when you have not got pregnant after so many years of TTC. In such cases of unexplained infertility, it is too hard to figure out what to do next.

Sometimes it could be as simple as some kind of nutritional deficiency, the inaccurate timing of sexual intercourse, a pre-existing health issue, or it may be that you need to explore options. It is important to cover all the basics, including additional testing that may need to take place. We are now going to cover the important areas that need to be focussed, some areas may or may not apply to you, but some may not have been taken into consideration when you were given your diagnosis.

What Role Hormonal Balance Play?

If the hormones are not balanced or there is some issues with the menstrual cycle is, it's hard to believe that you cannot get pregnant. Even if pregnancy does occur, the risk of miscarriage may increase. This is important for the male partner to know as well. Men can also have a hormonal imbalance as well, which may also create issues and difficulties in becoming pregnant due to poor sperm health or motility or sperm count, or other health-related issues.

What problems may women have?

Menstrual cycle irregularities or painful menses or excessive bleeding may be a sign of hormonal imbalance in women or other more severe fertility issues.

Unexpalined Infertility, Fertility Treatment

If any of the below hormones are not at the correct levels, the menstrual cycle may become irregular or you may face excessive bleeding or cramping. Hormonal imbalance may cause lots of other health related issues. For example thinning hair, heart palpitations, low libido, depression, overstress etc.

  • Progesterone
  • Estrogen
  • Follicle Stimulating Hormone (FSH)
  • Luteinizing Hormone (LH)
  • Androgens, for example, DHEA, Testosterone
  • Thyroid hormones
  • Prolactin

How Can Cervical Mucous Be A Problem?

Low cervical mucus is one of the most important factors to becoming pregnant. If the cervical mucus is nonexistent or too acidic, scant, then the sperm will not be able to make their way to the cervix.

What Are The Other Health Related Factors and Problems that Affect Both Women and Men’s Fertility?

Hormonal imbalance, poor egg health, low ovarian reserve, or poor/abnormal immune response which may affect conception badly. If you have any of the below health issues, it is very important to first watch out those issues, because problems with any of the below may directly impact your ability to conceive.

  • Thyroid issues
  • Poor Adrenal Health
  • Very low body weight
  • Obesity
  • Diabetes
  • Autoimmune disease
  • Smoking

Stress: Our bodies sometimes prevent the conception during the times of extreme stress. The presence of adrenaline and the hormone that is released by our bodies during some stressful times signals to our body that such conditions are not ideal for conception. It also makes the pituitary gland to release higher levels of prolactin, this also contributes to infertility that prevents conception from curing.

Male Infertility, Infertility

High stress levels can impact fertility for both female and male and need to opt for some fertility treatment.

What Are The Necessary Testing fordiagnosesa couple with unexplained infertility?

There is a wide range of infertility tests that doctors do before they diagnose a couple with such unexplained infertility issues. Be sure you get the following hormones tested.

Full hormone panel including:

  • Progesterone
  • Estradiol
  • Follicle Stimulating Hormone (FSH)
  • Luteinizing Hormone (LH)
  • Androgens (ex: testosterone/DHEA)
  • Thyroid hormone levels
  • Prolactin levels
  • Homocysteine levels
  • Immunological markers

What Is Immunological Fertility Testing?

A Reproductive Immunologist always differs from a Reproductive Endocrinologist, which most couples are referred, when infertility issues are not found by an OB-GYN.

  • Two or more than 2 miscarriages after the age of 35
  • Two IVF cycle failures after the age of 35
  • 3 or more miscarriages before the age of 35
  • 1 or more failed IVF before the age of 35
  • Pre-existing immune problems (Lupus, Rheumatoid Arthritis, MS)
  • Unexplained Infertility diagnosis
  • Previous pregnancies showing retarded and bad fetal growth
  • Endometriosis and at stage 1 & 2
  • Cold and flu-like symptoms, sore throat noted regularly after ovulation, IUI, or IVF transfer

What Are The Natural Options for Unexplained Infertility?

If you have been diagnosed with infertility for unknown reasons or unexplained fertility, what should you do then? Let’s start by taking a good look at daily lifestyle and eating habits and then what you can do naturally to conceive? You may need to opt for the fertility treatment.

Male Infertility, Fertility, Unexplained Infertility

The great thing about herbs and natural therapies or organic products is that the focus is on bringing the body back into balance to live a healthy life. With unexplained infertility, there are a few areas you can look into.

Eat a Fertility Diet: Diet and some foods are the most important way to support fertility health and even boost the fertility and avoid you going for the fertility treatment. Having a nutritional deficiency can cause the menstrual cycle to become imbalanced with irregular periods, may cause a lack of beneficial hormones to be produced, this may also contribute to poor sperm count and health or cause the body to lack overall health.

Eat Whole Foods: Fresh vegetables, fruits, raw seeds and nuts, whole grains, lean grass fed free range organic meats and dairy products. 

Dr. Sunil Eshwar

About The Author

Infertility Specialist, IVF Specialist Dr. Sunil Eshwar

Dr. Sunil Eshwar is an Infertility specialist who is presently specializing in laparoscopic surgery, high-risk pregnancies and infertility treatments such as IVF and IUI. Dr. Sunil Eshwar completed his MBBS from Bangalore Medical College and Research Institute in 2000 and MD from Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) in 2004. Later, he completed DNB from National Board of Examination in 2006. Dr. Sunil Eshwar is currently practicing at Apollo Fertility, Brookfield, Bangalore. For more information about Dr. Sunil Eshwar, visit elawoman.com


  1. Infertility profiling tests to check if not getting pregnant infertility, Elawoman - 2017
  2. Which are the most fertile days to plan pregnancy fertility, Elawoman - 2017
  3. Five things you need to know about fertility treatments fertility treatment, Elawoman - 2017
  4. 5 reasons for irregular periods irregular periods, Elawoman - 2017



Pratima Bishnu

My progesterone and estrogen level were variable since I took out my birth control patch after using it for one year. It took 6-7 months to normalize and then I was able to conceive.

June 30, 2018, 9:34 a.m. 4.5


Ashista Roy

I have a thyroid issue but I never had a problem like infertility. I think it's because of the healthy diet I have regularly.

Jan. 2, 2018, 11:02 a.m. 5.0


Varsha Gautam

Sexually transmitted diseases or STDs i.e. chlamydia or gonorrhea can cause irritation and perpetual scarring of the fallopian tubes. This can create obstacle in conceiving and can even cause infertility issues for a longer period of time in women.

Nov. 2, 2017, 2:29 p.m. 5.0


Shakti Priya

I have read some facts regarding infertility. It's been found that In Europe, North America and in other parts of the world, 85% of the couples (approx) will conceive within one year if they have regular unprotected sex. The rest 15% have some kind of health issues or it's their lifestyle that hi...

Nov. 2, 2017, 2:24 p.m. 4.5


Nitya Rathore

My son has diabetes at very younger age, will he have trouble like infertility in future? What can I do other than feeding him healthy food?

May 16, 2017, 9:57 a.m. 5.0

View all comments

Leave a Comment



The information displayed on this webpage covers general information on several medical conditions, fertility treatments, IVF ICSI, surrogacy procedure, home remedies, and their respective treatments. The exclusive purpose of the displayed information is for the sake of general understanding and it has been collected from open sources which heavily rely on research and laboratory tests. However, the information shared here should not be considered as a medical advice or an alternative to consultation with a registered medical practitioner or licensed healthcare professional.

It is not advised to self-diagnose or treat any medical condition or disease following the information given in this article. We insist you to consult a registered practitioner and never try to replace their advice or discontinue treatment in between by relying solely on the information obtained. External links to different websites as well as videos given on the website serve the purpose of sharing knowledge only. Ela being an Independent Medical Information platform is neither responsible nor guarantees the authenticity, reliability, and accuracy of these videos and websites in any way. We do not intend the information displayed here to be used for a medical emergency, if you seek medical attention for yourself (or any other person with whom you want to share the information with), we advise you to directly get in touch with the hospital or the doctor.

Related Article view all

Fertility Basics
How are surrogate mothers screened?
Dr. Bhavna Banga
Dr. Bhavna Banga 4.8 (6 Votes)

How are surrogate mothers screened?

A surrogate mother is expected to be prepared for the upcoming pregnancy and to have a total commitment towards the process. Checking surrogate mothers medical history, previous pregnancy history, current medical report including blood tests and hormone tests, family background and her mental stability to carry a child are the some of the ways to screen a surrogate mother.

Read More

Fertility Basics
PCOS and Infertility - How to Get Pregnant With PCOS
Dr. Pranay Shah
Dr. Pranay Shah 4.8 (6 Votes)

PCOS and Infertility - How to Get Pregnant With PCOS

Women suffering from PCOS find it very hard to get pregnant because of irregualrity in the menstrual cycle and ovulation. But it is possible to get pregnant with PCOS by following healthy diet and starting medications such as clomid, letrozole or gonadotrophins. If nothing works, then one can opt for Ovarian Drilling and Fertility treatment (IVF).

Read More

Fertility Basics
Can Clomid Tablet Result in Twins or Multiple Births?

Can Clomid Tablet Result in Twins or Multiple Births?

Yes, the clomid tablet can result in twins or multiple births. There are 5 to 8% of chances of conceiving twins while being on Clomid as compared to natural twin pregnancy, which has just 1 to 2% chances. Intake of Clomid results in the overproduction of egg stimulating hormones, which further causes, the release of more than 1 egg from the ovary.

Read More

More From Author

Fertility Basics
Causes and Natural Remedies for Infertility
Dr. Sunil Eshwar
Dr. Sunil Eshwar 4.6 (6 Votes)

Causes and Natural Remedies for Infertility

Infertility is the inability to conceive or carry a pregnancy to fu...

Read More

Fertility Basics
Infertility Profiling Tests to Check if not Getting Pregnant
Dr. Sunil Eshwar
Dr. Sunil Eshwar 4.6 (7 Votes)

Infertility Profiling Tests to Check if not Getting Pregnant

Infertility Profiling Tests help you pin down the reason behind you...

Read More

Fertility Basics
Environmental and Occupational Factors Affecting Female Fertility
Dr. Sunil Eshwar
Dr. Sunil Eshwar 4.6 (6 Votes)

Environmental and Occupational Factors Affecting Female Fertility

About one third of infertility cases in the world are due to women ...

Read More

Trending Articles


5 Best Surrogacy Doctors in India

Find the list of best surrogacy doctors in India who offers the best treatment with the highest success rate. The list has been categorized on the basis of doctors fame, experience, reviews, ratings, and cost. Dr. Mohit Saraogi from Saraogi Hospitals and IRIS IVF Centre and Dr. Kaberi Banerjee from Advanced Fertility Centre top the list of the best surrogacy doctors in India.

Read More 4.5 (1 Votes)


Best IVF Doctors in India with Highest Success Rates

Find here the list of best IVF doctors in India on the basis of Ratings, Success Rate, Services offered, IVF cost packages and available Facilities. Dr. Nisha Bhatnagar, Dr. Kaberi Banerjee and Dr. Anjali A Deval top the list of such IVF doctors in India due to their unique pricing system, popularity and high success rate.

Read More 4.7 (3 Votes)


Top Surrogacy Centres in India with Highest Success Rates

In this article we bring you the best Surrogacy Centres and clinics in India with Review Ratings, Cost Estimates, and Surrogacy Success Rate to help you make the best choice. Aveya IVF and Surrogacy Centre and Advanced Fertility and Surrogacy Centre tops the list of such surrogacy centres in India due to their low treatment costs, popularity and high success rates.

Read More 4.8 (2 Votes)